Evidence Synthesis @CRSU

1) Exploring the experiences of adults, their care partners and care home staff around moving into care home settings and identifying interventions which support the move: a mixed methods systematic review

• The Protocol

2) Modifiable Factors Associated with Good Mental Health Outcomes in Veterans

What modifiable individual, social, and service-related factors are associated with good mental health outcomes in veterans, including those exposed to trauma?

This question is directly aligned with James Lind Alliance Priority 10 for Veterans’ Health Research and underscores the need to move beyond evaluating the effectiveness of discrete interventions in isolation. Instead, it seeks to understand the modifiable mechanisms, contexts, and enabling conditions that support good mental health outcomes among veterans, including those who have experienced traumatic or stressful events during service. While the review title is presented in a format consistent with PICOS conventions, this review will be conducted as a convergent integrated mixed methods systematic review (MMSR), in line with Joanna Briggs Institute guidance, to support the synthesis of quantitative, qualitative, and mixed-methods evidence addressing complex, multi-level determinants of mental health.

This review is commissioned by the Ministry of Defence, and the protocol is currently in development.

1) Prognostic accuracy of multicomponent prognostic models for predicting last six months of life an overview of reviews 

• The Protocol

2) What do the most effective, most cost-effective and best value Integrated disease management (IDM) Programmes for people with Chronic Obstructive Pulmonary Disease (COPD) contain?

• The Protocol

3) Exploring the experiences of adults, their care partners and care home staff around moving-in to care home settings and identifying interventions which support the move: a mixed methods systematic review

4) What are effective and safe pharmacological and non-pharmacological interventions for managing insomnia and sleep fragmentation in children with moderate to severe cerebral palsy?

• Commissoned by the James Lind Alliance. Commenced March 2025. Completed in December 2025.

HPV Self-Sampling for Cervical Cancer Screening: A Rapid Review

• Commissioned by the National Screening Committee and completed in August 2025.

Regional anaesthesia for reducing the incidence and severity of chronic pain after surgery: A living systematic review and network meta-analysis.

• Commenced in May 2024 and completed in May 2025. This review also includes a study within a review (SWAR) on Use of AI for extraction of outcome data .

Review of modelling studies and cost-effectiveness analyses for UK cancer screening programmes

• Commisioned by the National Screening Committee and commenced October 2024. Completed in September 2025. 

UK NSC Position Statement: Incidental Findings in Economic Evaluation of Screening Programmes

• Commissioned by the National Screening Committee in September 2024 this is a follow on piece of work from the review completed in 2023. Expected to complete in late 2025. 

At What Levels of Expected Blood Loss from Surgery is Tranexamic Acid (TXA) Effective at Reducing the Need for Blood Transfusion?

• Commissioned by NICE, this project completed in November 2024.

Prognostic Accuracy of Prediction Tools for Surgical Bleeding Risk

• Commissioned by NICE, the manuscript for this project is currently awaiting acceptance to a peer reviewed journal. 
• Plain Language Summary - Blood loss prediction tools  

Defining Incidental Findings in Economic Evaluations of Screening Programmes: a Scoping Review

• This project was commissioned by the National Screening Centre. The final report was delivered in November 2023. 

• Plain Language Summary -Incidental findings